Aim of this research was to develop a simple, precise, accurate and reproducible first order derivative method spectrophotometric method for estimation of aripiprazole and escitalopram oxalate in combination of synthetic mixture in 1: 3 ratios and validate it as per ICH guidelines. The method is based on first order UV derivative spectrophotometry. Methanol was selected as a solvent for estimation of aripiprazole at ZCP of escitalopram oxalate 297 nm and for escitalopram oxalate at ZCP of aripiprazole 286 nm in linearity range 5-25 µg/ml and 15-75 µg/ml respectively. The correlation coefficient (r2) for aripiprazole was 0.995 and for escitalopram oxalate 0.997. The mean % recovery was found to be in range of 99.55%-101.00% for aripiprazole and 100.15%-101.16% for escitalopram oxalate. The result of analysis has been validated statistically and recovery studies recommended for routine since it is rapid, simple, accurate and sensitive.
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